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Abstract #4170

Brain cortical thickness abnormalities in untreated, first-episode adult patients with major depressive disorder

Youjin Zhao1, Huaiqiang Sun1, Su Lui1, and Qiyong Gong1

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, People's Republic of

The present study aimed to use surface-based morphometric analysis to characterize the alteration of cortical thickness in first-episode never-medicated adult MDD patients. 37 MDD patients and 41 healthy controls were enrolled. Results showed increased cortical thickness (p<0.05, False Discovery Rate) in left anterior and posterior cingulate cortex extending to medial superior frontal cortex, bilateral precentral cortex, left paracentral cortex, bilateral superior parietal cortex, left temporal poles, and right lateral occipital cortex in MDD patients than HC group. The data provide evidence that even early in the course of depression brain regions involved in mood regulation show cortical thickness abnormalities.

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