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Abstract #4172

Multiparametric MR imaging of oxygen metabolism and angiogenesis for detection of recurrence or grade increase in glioma patients

Andreas Stadlbauer1, Max Zimmermann1, Karl Rössler1, Stefan Oberndorfer2, Michael Buchfelder1, and Gertraud Heinz3

1Department of Neurosurgery, University of Erlangen, Erlangen, Germany, 2Department of Neurology, University Clinic of St. Pölten, St. Pölten, Austria, 3Department of Radiology, University Clinic of St. Pölten, St. Pölten, Austria

Early detection of recurrence is crucial in patient care, but differentiation of treatment related necrosis from recurrent neoplasm is often difficult with conventional MRI (cMRI). We evaluated the usefulness for glioma recurrence grade increase detection of a multiparametric MRI for combined exanimation of oxygen metabolism and microvessel architecture. Forty-one patients with suspected recurrent glioma and one patient under antiangiogenic therapy were examined using vascular architecture mapping (VAM) and multiparametric quantitative BOLD (mp-qBOLD). 57% of LGG-patients, 22% of glioma WHO°III, and 32% of glioblastoma patients which were diagnosed as unsuspicious showed changes in oxygen metabolism and microvasculature indicative for recurrence.

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