Abstract #4174

Assessment of changes in structural connectivity of the central executive network during cranial radiotherapy in children treated for medulloblastoma

Wilburn E Reddick¹, John O Glass¹, Elizabeth C Duncan¹, Jung Won Hyun², Qing Ji¹, Yimei Li², and Amar Gajjar³

¹Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, ²Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States, ³Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States

Diffusion tensor imaging from 30 childhood medulloblastoma patients were analyzed to assess changes in structural connectivity of the central executive network (CEN) in response to cranial irradiation. Significant drops in fractional anisotropy and axial diffusivity (AX) were demonstrated in most of the CEN subnetworks after irradiation. Furthermore, patients receiving the highest CRT dose had significantly decreased AX in all subnetworks of the CEN. These findings suggest significant reduction in the microstructural integrity within the CEN immediately after CRT in this population and support the use of the CEN model for evaluating changes in cerebral white matter early in therapy.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.