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Abstract #4176

High grade intracranial gliomas exhibit widespread impaired cerebrovascular reactivity

Christiaan Hendrik Bas van Niftrik1, Marco Piccirelli2, Jan-Karl Burkhardt1, Athina Pangalu2, Antonio Valavanis2, Michael Weller3, Oliver Bozinov1, Luca Regli1, and Jorn Fierstra1

1Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland, 2Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, 3Department of Neurology, University Hospital Zurich, Zurich, Switzerland

Neurovascular uncoupling (false negative BOLD activation) can be found in patients with high grade gliomas. An underlying mechanism could be impaired cerebrovascular reactivity. We determined overall cerebrovascular reactivity (CVR) as well as the perifocal CVR and used a healthy control group. We applied an automated tumor masking with determination of CVR in 7 consecutive rings of 3 mm. We found an overall impaired CVR as well as significantly impaired intratumoral CVR and perifocal up to 12 mm. No such trend was found on the contralateral hemisphere, after flipping of the tumor mask.

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