Abstract #4187

Characterization of Pediatric Brain Tumors and Treatment Effect using Magnetic Resonance Fingerprinting: Initial Experience

Peter de Blank^1,2, Dan Ma², Chaitra Badve², Shivani Pahwa², Sara Dastmalchian³, Duncan Stearns^1,2, Deborah Rukin Gold^2,4, Krystal Tomei^2,5, Jill S Barnholtz-Sloan², Andrew Sloan^2,5, Vikas Gulani^2,6, and Mark Griswold²

¹Pediatrics, University Hospitals, Cleveland, OH, United States, ²Case Western Reserve University, Cleveland, OH, United States, ³University Hospitals, Cleveland, OH, United States, ⁴Neurology, University Hospitals, Cleveland, OH, United States, ⁵Surgery, University Hospitals, Cleveland, OH, United States, ⁶Radiology, University Hospitals, Cleveland, OH, United States

This study uses magnetic resonance fingerprinting to investigate relaxometry values in pediatric and young adult primary brain tumors. Six children with primary brain tumors were scanned: 3 with low-grade tumors and 3 with high-grade tumors. T1 and T2 values of tumor were significantly different from contralateral white matter. T1, T2 quantification of tumor were also significantly different between high- and low-grade tumors. Three subjects underwent serial observations: 2 received therapy and 1 did not. Subjects that underwent surgical decompression and chemotherapy appeared to have larger changes in T1 values than those that were only observed.

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