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Abstract #4188

Assessment of Global and Regional Cerebral White Matter Changes Induced by Cranial Radiotherapy in Childhood Brain Tumor Patients Using a Structural Connectivity Network Approach

Qing Ji1, John O. Glass1, Elizabeth C. Duncan1, Amar Gajjar2, and Willburn E. Reddick1

1Diagnostic Imaging, St.Jude Children's Research Hospital, Memphis, TN, United States, 2Oncology, St.Jude Children's Research Hospital, Memphis, TN, United States

Global and regional cerebral white matter changes induced by cranial radiotherapy (CRT) were analyzed by comparing Pre-CRT and Post-CRT diffusion tensor imaging (DTI) from 30 childhood medulloblastoma patients using a structural connectivity network model and graph theory approaches. At the global level, global network efficiency and character path were significantly changed for the whole network. At the regional level, 17 of 82 network nodes had significantly decreased local efficiencies, and 14 of those nodes also had significantly decreased clustering coefficients. These findings suggest significant reduction in the microstructural integrity immediately after CRT in this population.

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