Abstract #4189

Characteristics of apparent relative oxygen extraction fraction (rOEF) in human high grade glioma

Christine Preibisch^1,2, Mathias Lukas³, Anne Kathrin Kluge¹, Claus Zimmer¹, Stefan Förster^3,4, and Thomas Pyka³

¹Dept. of Neuroradiology, Technische Universität München, Munich, Germany, ²Clinic for Neurology, Technische Universität München, Munich, Germany, ³Clinic for Nuclear Medicine, Technische Universität München, Munich, Germany, ⁴Clinic for Nuclear Medicine, Klinikum Bayreuth, Bayreuth, Germany

Hypoxia plays an important role in prognosis and therapy response of cancer. This study explores the characteristics of multi-parametric measurements of relative oxygen extraction fraction (rOEF) in a sample of 36 mostly high grade glioma patients. This study confirms previous results in human glioma where rOEF values were found to increase with tumor grade but does not find a similar increase of a supposedly hypoxic tumor area with tumor grade. According to present results, high rOEF values, supposedly corresponding to a high oxygen extraction, prevail in edematous tissue with low rCBV. Whether this translates into tissue hypoxia, needs further investigation.

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