Abstract #4195

How much microvascular anatomy is in T1-DCE MRI? – A computerized analysis of meningioma microvasculature correlated to kinetic parameters applying the extended Tofts model

Vera Catharina Keil¹, Kanishka Hiththetiya², Gerrit H. Gielen³, Matthias Simon⁴, Bogdan Pintea⁴, Anna Vogelgesang¹, Juergen Gieseke^1,5, Burkhard Maedler⁵, Hans Heinz Schild¹, and Dariusch Reza Hadizadeh¹

¹Department of Radiology, Universitätsklinikum Bonn, Bonn, Germany, ²Center for Pathology, Universitätsklinikum Bonn, Bonn, Germany, ³Department of Neuropathology, Universitätsklinikum Bonn, Bonn, Germany, ⁴Clinic for Neurosurgery and Stereotaxy, Universitätsklinikum Bonn, Bonn, Germany, ⁵Philips Healthcare, Best, Netherlands

Tissue perfusion is co-defined by anatomical factors of the microvasculature. If and how kinetic parameters of T1w dynamic-contrast enhanced (T1-DCE) MRI fit into this anatomical perfusion model, is a topic of on-going discussion. Based on the extended Tofts model (ETK) we therefore performed a focal analysis of kinetic parameters in meningioma and surgically retrieved precisely corresponding tissue specimens. Their microvasculature underwent multimodal computerized analysis. Kinetic parameters were found to correlate poorly and inconsistently with the microvascular anatomy on both an inter- and intra-individual level.

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