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Abstract #4195

How much microvascular anatomy is in T1-DCE MRI? – A computerized analysis of meningioma microvasculature correlated to kinetic parameters applying the extended Tofts model

Vera Catharina Keil1, Kanishka Hiththetiya2, Gerrit H. Gielen3, Matthias Simon4, Bogdan Pintea4, Anna Vogelgesang1, Juergen Gieseke1,5, Burkhard Maedler5, Hans Heinz Schild1, and Dariusch Reza Hadizadeh1

1Department of Radiology, Universitätsklinikum Bonn, Bonn, Germany, 2Center for Pathology, Universitätsklinikum Bonn, Bonn, Germany, 3Department of Neuropathology, Universitätsklinikum Bonn, Bonn, Germany, 4Clinic for Neurosurgery and Stereotaxy, Universitätsklinikum Bonn, Bonn, Germany, 5Philips Healthcare, Best, Netherlands

Tissue perfusion is co-defined by anatomical factors of the microvasculature. If and how kinetic parameters of T1w dynamic-contrast enhanced (T1-DCE) MRI fit into this anatomical perfusion model, is a topic of on-going discussion. Based on the extended Tofts model (ETK) we therefore performed a focal analysis of kinetic parameters in meningioma and surgically retrieved precisely corresponding tissue specimens. Their microvasculature underwent multimodal computerized analysis. Kinetic parameters were found to correlate poorly and inconsistently with the microvascular anatomy on both an inter- and intra-individual level.

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