Abstract #4215

Reconstruction Using Compressed Sensing with Edge Preservation for High Resolution MR Characterization of Myocardial Infarction: In-Vivo Preclinical Validation

Li Zhang^1,2, Jennifer Barry², Mihaela Pop^1,2, and Graham A Wright^1,2

¹Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Multi-contrast late enhancement (MCLE)¹ images offer better visualization of myocardial infarction (MI) than conventional IR-FGRE. However, current MR images either with IR-FGRE or MCLE provide an inferior spatial resolution of 1.6-2.0mm in-plane with a slice thickness of 5-8mm in the clinical setting. Characterization of infarct heterogeneity requires high spatial resolution. We propose a novel method to reconstruct MCLE images at a high spatial resolution from a highly accelerated dataset acquired prospectively with three-dimensional (3D) MCLE. The method was validated in a preclinical model, producing an isotropic resolution of 1.5mm within a single breath-hold.

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