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Abstract #4216

Accelerated MP2RAGE Imaging Using Sparse Iterative Reconstruction

Emilie Mussard1,2,3, Tom Hilbert1,2,3, Reto Meuli2, Jean-Philippe Thiran2,3, and Tobias Kober1,2,3

1Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

MP2RAGE is a T1 imaging method providing greatly reduced B1 bias as well as less T2* and PD-contributions. It requires, however, long acquisition time (standard protocol with GRAPPAx3: ~8min) which hampers its clinical application. This work proposes to use sparse iterative reconstruction techniques to shorten MP2RAGE acquisition times. Resulting images are benchmarked using contrast assessment, changes in obtained T1 values as well as evaluating the effect of undersampling on an automated brain morphometry algorithm. Acceptable penalty in image quality and morphometric outcome was achieved with up to 5-fold acceleration, yielding a measurement time of 3.8min compared to fully sampled 20min.

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