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Abstract #4326

Semi-Automatic Comparison of Myocardial Tissue Injury using a Non-Rigid Registration Method in patients with non-ischemic disease

Leili Riazy1, Simone Fritzschi2,3, Arthur Stötzner2,3, Fabian Mühlberg2,3, Luisa Schmacht2,3, Matthias Dieringer1,2,4, Florian von Knobelsdorff-Brenkenhoff2,3, Thoralf Niendorf1,2, and Jeanette Schulz-Menger2,3

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center (ECRC), Berlin, Germany, 3Department of Cardiology and Nephrology, HELIOS Klinikum Berlin Buch, Berlin, Germany, 4Siemens Healthcare GmbH, Erlangen, Germany

Late Gadolinium Enhancement (LGE) is the noninvasive gold standard for focal fibrosis, parametric mapping with and without contrast-media enable detection of diffuse fibrosis. We developed a non-rigid registration method to superimpose LGE images and T1-Maps allowing for pixel-wise comparison of LGE extent and abnormal T1 times. We observed significantly larger regions of ECV, T1 native and post-contrast abnormalities than LGE positive areas. However, LGE was not always completely covered by abnormalities of any of the mentioned parameters.

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