Abstract #4342

Cerebral blood volume MRI elucidates the impact of ERK1 on high grade glioma growth and invasion

Min-Chi Ku¹, Andreas Pohlmann¹, Sonia Waiczies¹, Joao dos Santos Periquito¹, Till Huelnhagen¹, and Thoralf Niendorf¹

¹Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Glioma progression involves complex interactions of tumor vasculature and infiltrating anti-tumor immune cells. As we previously found that mouse lacking ERK1 formed significantly smaller tumors, it was still not clear whether ERK1 deletion in the tumor vascular architecture might influence the outcome of glioma growth. To further study this, we examined the relative cerebral blood volume (rCBV) in the glioma tumor. R₂* changes induced by a blood-pool contrast agent, ferumoxytol, were quantified. Here, we established a model system to noninvasively monitor brain tumor angiogenesis, and found evidence supporting the role of ERK1 in regulating glioma growth via angiogenesis.

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