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Abstract #4346

Chemotherapy increases anti-correlation between default mode and attention networks

Suresh Emmanuel Joel1, Roberto Garcia Alvarez2, Juan Bachiller Egea3, Lucia Gonzalez Cortijo4, Vincente Martinez de Vega3, Rakesh Mullick1, and Mar Jimenez de la Pena3

1General Electric Global Research, Bangalore, India, 2General Electric Healthcare, Madrid, Spain, 3Departamento Diagnostico por la imagen, Hospital Universitario Quiron, Madrid, Spain, 4Departamento de Oncología Médica, Hospital Universitario Quiron, Madrid, Spain

More than three-fourth of chemotherapy treated cancer survivors have cognitive impairment, including memory loss, inability to think, lasting several years after completion of therapy, sometimes labelled as ‘chemobrain’. Previously, the default mode network (DMN) has been shown to be specifically vulnerable to chemotherapy. In this study we study changes in DMN connectivity after chemotherapy within the same patients. In healthy adults, the DMN is anti-correlated to task positive networks. We observe an increase in this anti-correlation between DMN regions and task positive network regions post-chemotherapy.

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