Abstract #4346

Chemotherapy increases anti-correlation between default mode and attention networks

Suresh Emmanuel Joel¹, Roberto Garcia Alvarez², Juan Bachiller Egea³, Lucia Gonzalez Cortijo⁴, Vincente Martinez de Vega³, Rakesh Mullick¹, and Mar Jimenez de la Pena³

¹General Electric Global Research, Bangalore, India, ²General Electric Healthcare, Madrid, Spain, ³Departamento Diagnostico por la imagen, Hospital Universitario Quiron, Madrid, Spain, ⁴Departamento de Oncología Médica, Hospital Universitario Quiron, Madrid, Spain

More than three-fourth of chemotherapy treated cancer survivors have cognitive impairment, including memory loss, inability to think, lasting several years after completion of therapy, sometimes labelled as ‘chemobrain’. Previously, the default mode network (DMN) has been shown to be specifically vulnerable to chemotherapy. In this study we study changes in DMN connectivity after chemotherapy within the same patients. In healthy adults, the DMN is anti-correlated to task positive networks. We observe an increase in this anti-correlation between DMN regions and task positive network regions post-chemotherapy.

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