Meeting Banner
Abstract #4347

Predicting overall survival in glioblastoma patients from DTI, DCE and DSC MRI data acquired prior to surgery and post-chemoradiotherapy

Lawrence Kenning1, Martin Lowry2, Martin D Pickles1, Chris Roland Hill3, Shailendra Achawal3, and Chittoor Rajaraman3

1Centre for MR Investigations, Hull York Medical School at University of Hull, Hull, United Kingdom, 2Hull York Medical School at University of Hull, Hull, United Kingdom, 3Hull and East Yorkshire Hospitals NHS Trust, Hull, United Kingdom

DTI, DCE and DSC MRI parameters obtained pre-surgery and post-chemoradiotherapy were used to predict overall survival in a cohort of patients with glioblastoma multiforme. Results suggest that preoperative diffusivity measurements contain prognostic information about survival. Following chemoradiotherapy, Ktrans, ve, rCBV and tumour volumes were found to have significant prognostic value with higher values associated with shorter overall survival. Cox regression analysis identified 2 volumes and 2 MR parameters, confirming the Kaplan-Meier findings that preoperative DTI and post-chemoradiotherapy DCE parameters have added prognostic value to more traditional prognostic features such as tumour volume.

This abstract and the presentation materials are available to members only; a login is required.

Join Here