Abstract #4347

Predicting overall survival in glioblastoma patients from DTI, DCE and DSC MRI data acquired prior to surgery and post-chemoradiotherapy

Lawrence Kenning¹, Martin Lowry², Martin D Pickles¹, Chris Roland Hill³, Shailendra Achawal³, and Chittoor Rajaraman³

¹Centre for MR Investigations, Hull York Medical School at University of Hull, Hull, United Kingdom, ²Hull York Medical School at University of Hull, Hull, United Kingdom, ³Hull and East Yorkshire Hospitals NHS Trust, Hull, United Kingdom

DTI, DCE and DSC MRI parameters obtained pre-surgery and post-chemoradiotherapy were used to predict overall survival in a cohort of patients with glioblastoma multiforme. Results suggest that preoperative diffusivity measurements contain prognostic information about survival. Following chemoradiotherapy, K^trans, v_e, rCBV and tumour volumes were found to have significant prognostic value with higher values associated with shorter overall survival. Cox regression analysis identified 2 volumes and 2 MR parameters, confirming the Kaplan-Meier findings that preoperative DTI and post-chemoradiotherapy DCE parameters have added prognostic value to more traditional prognostic features such as tumour volume.

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