Abstract #4348

Optimizing Magnetization Prepared Rapid Gradient Echo (MPRAGE) for Brain Tumor Detection

Jinghua Wang¹, Mark Smith², and Lili He³

¹The Ohio State University, Columbus, OH, United States, ²Radiology, Nationwide Children’s Hospital, Columbus, OH, United States, ³Center for Perinatal Research, Nationwide Children’s Hospital, Columbus, OH, United States

Gadolinium based contrast agents decrease T₁ times in pathologic regions of the brain and improve image contrast and lesion visualization with increased sensitivity and specificity. Magnetization Prepared Rapid Gradient Echo (MPRAGE) sequence offer thinner slices, near seamless reformatting options, and lower specific absorption rates than 2D spin-echo based technique. In this study, we optimize MPRAGE sequence using computer simulation to improve brain tumor enhancement and detection. Compared with a Siemens default MPRAGE sequence, our optimized protocol greatly shortened scan time by around 60% without sacrificing tumor delectation sensitivity.

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