Abstract #4352

Enhanced brain labeling by atlas registration in Neuro-oncology using virtual tumor shrinking

Hariharan Ravishankar¹, Igor Barani², Sheshadri Thiruvenkadam¹, Marc Mabray², KS Shriram¹, SoonMee Cha², Rakesh Mullick³, and Suresh Emmanuel Joel³

¹General Electric Global Research, Bangalore, India, ²University of California at San Francisco, San Francisco, CA, United States, ³Diagnostic Imaging and Biomedical Technologies, General Electric Global Research, Bangalore, India

In this work, we address the problem of registration of brain images to atlases in presence of large, space-occupying tumor pathologies. We provide an integrated registration framework to address two types of tumors - a) infiltrating tumors - which penetrate the surrounding tissues b) extrinsic tumors - which grow and compress the surrounding tissues. We propose a mathematical model to shrink extrinsic tumors before registration, thereby reversing the compression effects.

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