Abstract #4356

Changes in DTI and DSC Parameters as Markers for Assessing Treatment Response in Glioblastomas

Sumei Wang¹, Sanjeev Chawla¹, Maria Martinez-Lage², Tianyu Yin¹, Gaurav Verma¹, Robert A Lustig³, Steven Brem⁴, Suyash Mohan¹, Ronald L Wolf¹, Arati Desai⁵, and Harish Poptani⁶

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States, ⁵Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, United States, ⁶Cellular and Molecular Physiology, University of Liverpool, Liverpool, United Kingdom

The study was performed to determine whether changes in DTI and DSC parameters can aid in differentiating glioblastomas with pseudo-progression (PsP) from true-progression (TP) and partial response. MRI data from thirty patients with these diagnoses (based on pathological evaluation and clinical follow-up) were included. All patients underwent two MR scans before pathological confirmation. A significant increase in median rCBV and rCBV_max value was noted in TP compared with PsP, while none of the DTI parameters showed significant differences between groups. Our preliminary results indicate that changes in rCBV may be helpful in identifying PsP from TP.

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