Abstract #4357

Which is the best predictor for histological grade of glioma: DWI, MRS, 11C-methionine -, and 18F-fluorodeoxyglucose -PET

Keiichi Kikuchi¹, Yoshiyasu Hiratsuka¹, Shiro Ohue², Shohei Kohno², and Teruhito Mochizuki¹

¹Radiology, Ehime University School of Medicine, Ehime, Japan, ²Neurosurgery, Ehime University School of Medicine, Ehime, Japan

Various imaging modalities are commonly used for preoperative examinations of brain tumors. Here we evaluated the specificity of ADC, MRS, and PET-CT to predict the WHO glioma grade and identified potential correlations with the Ki-67 index as a marker of tumor cell proliferation. In this limited patients series, minimum ADC was the best predictor of the histological glioma grade and it was also significantly negatively correlated with the Ki-67 index indicating its potential as a reliable marker of cellular proliferation.

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