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Abstract #4364

Cell treatment improves recovery after stroke in type two diabetic rats measured by MRI

Guangliang Ding1, Jieli Chen1, Michael Chopp1,2, Lian Li1, Tao Yan1,3, Esmaeil Davoodi-Bojd1, Qingjiang Li1, Chengcheng Cui1, Siamak P.N. Davarani1, and Quan Jiang1

1Neurology, Henry Ford Health System, Detroit, MI, United States, 2Physics, Oakland University, Rochester, MI, United States, 3Tianjin Geriatrics Institute, Tianjin Medical University General Hospital, Tianjin, China, People's Republic of

With a suture 2-hour occlusion and reperfusion stroke model and a low dose Streptozotocin injection combined with a high fat food diet diabetic model of young adult Wistar rats, longitudinal measurements of MRI demonstrated that bone marrow stromal cell treatment of stroke in type 2 diabetes mellitus rats, compared with the saline treated control rats, not only significantly reduced blood-brain barrier leakage and hemorrhagic spots starting from 1 week and 3 weeks after stroke (p<0.05) measured by contrast enhanced T1WI with Gd-DTPA and identified by SWI, respectively; but also significantly improves white matter remodeling after stroke measured by DSI.

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