Abstract #4364

Cell treatment improves recovery after stroke in type two diabetic rats measured by MRI

Guangliang Ding¹, Jieli Chen¹, Michael Chopp^1,2, Lian Li¹, Tao Yan^1,3, Esmaeil Davoodi-Bojd¹, Qingjiang Li¹, Chengcheng Cui¹, Siamak P.N. Davarani¹, and Quan Jiang¹

¹Neurology, Henry Ford Health System, Detroit, MI, United States, ²Physics, Oakland University, Rochester, MI, United States, ³Tianjin Geriatrics Institute, Tianjin Medical University General Hospital, Tianjin, China, People's Republic of

With a suture 2-hour occlusion and reperfusion stroke model and a low dose Streptozotocin injection combined with a high fat food diet diabetic model of young adult Wistar rats, longitudinal measurements of MRI demonstrated that bone marrow stromal cell treatment of stroke in type 2 diabetes mellitus rats, compared with the saline treated control rats, not only significantly reduced blood-brain barrier leakage and hemorrhagic spots starting from 1 week and 3 weeks after stroke (p<0.05) measured by contrast enhanced T1WI with Gd-DTPA and identified by SWI, respectively; but also significantly improves white matter remodeling after stroke measured by DSI.

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