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Abstract #4365

The MIPP study: Monitoring Intracranial atherosclerotic Plaque Progression using high resolution MRI - initial results

Chengcheng Zhu1, Xuefeng Zhang2, Andrew J Degnan3, Qi Liu2, Luguang Chen2, Zhongzhao Teng4, David Saloner1, and Jianping Lu2

1Radiology, University of California, San Francisco, San Francisco, CA, United States, 2Radiology, Changhai Hospital, Shanghai, China, People's Republic of, 3Radilogy, University of Pittsburgh, Pittsburgh, PA, United States, 4Radiology, University of Cambridge, Cambridge, United Kingdom

Intracranial large artery atheroma is a major cause of stroke, however its natural history is still poorly understood. In this study we followed 63 symptomatic patients who had intracranial atherosclerotic plaque for up to 3 years. Multi-contrast black blood vessel wall MRI and clinical brain imaging were performed. Initial results included 22 patients who were followed for 6 months showed an overall plaque volume progression rate of 0.8%, however with a large standard deviation (20.1%) and range (-45.9% to 40.1%). Patients with hypertension or low HDL tended to progress faster. The feasibility of MRI for monitoring intracranial plaque pathological changes was demonstrated.

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