Abstract #4368

High Resolution Whole Brain Intracranial Vessel Wall Imaging at 3T and 7T

Chengcheng Zhu¹, Henrik Haraldsson¹, Karl Meisel², Nerissa Ko², Michael Lawton³, John Grinstead⁴, Sinyeob Ahn⁴, Gerhard Laub⁴, Christopher Hess¹, and David Saloner¹

¹Radiology, University of California, San Francisco, San Francisco, CA, United States, ²Neurology, University of California, San Francisco, San Francisco, CA, United States, ³Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States, ⁴Siemens Healthcare, San Francisco, CA, United States

High resolution MRI of the intracranial vessel wall provides important capabilities for the assessment of intracranial vascular disease including atherosclerotic plaques and aneurysms. This study developed and optimized 3D high resolution (0.5mm isotropic) techniques for intracranial vessel wall imaging at 3T and 7T. The abilities of 3T clinical scanners and 7T research scanners were systematically compared through theoretical simulations and in vivo patient studies. We found 3D T1-weighted SPACE sequence could be used for whole brain intracranial vessel wall evaluation at both 3T and 7T. 7T provides significantly better image quality and improves the confidence of diagnosis.

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