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Abstract #4369

Altered Temporal Dynamics in BOLD Measurements of Vascular Reserve in Children with Sickle Cell Disease

Jackie Leung1, James Duffin2, and Andrea Kassner1,3

1Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 2Physiology, University of Toronto, Toronto, ON, Canada, 3Medical Imaging, University of Toronto, Toronto, ON, Canada

Cerebrovascular reactivity (CVR) measured with BOLD MRI can be robustly acquired by altering blood flow with a square-wave CO2 stimulus. However, the BOLD response to a step change is confounded by a temporal lag and transient period of signal change. Differences in temporal response between different tissues can lead to CVR underestimation. Transfer function analysis (TFA) provides a frequency domain analysis of CVR that is less sensitive to temporal variations. This study compares the results of TFA to conventional CVR analysis in children with and without sickle cell disease.

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