Altered Temporal Dynamics in BOLD Measurements of Vascular Reserve in Children with Sickle Cell Disease
Jackie Leung1, James Duffin2, and Andrea Kassner1,3
1Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 2Physiology, University of Toronto, Toronto, ON, Canada, 3Medical Imaging, University of Toronto, Toronto, ON, Canada
Cerebrovascular reactivity (CVR)
measured with BOLD MRI can be robustly acquired by altering blood flow with a square-wave
CO2 stimulus. However, the BOLD response to a step change is
confounded by a temporal lag and transient period of signal change. Differences
in temporal response between different tissues can lead to CVR underestimation.
Transfer function analysis (TFA) provides a frequency domain analysis of CVR
that is less sensitive to temporal variations. This study compares the results
of TFA to conventional CVR analysis in children with and without sickle cell
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