Abstract #4370

Diffusion Corrected Aneurysm Wall Permeability as a Measure of Rupture Risk

Charles G Cantrell¹, Parmede Vakil^1,2, Sameer A Ansari³, and Timothy J Carroll^1,3

¹Biomedical Engineering, Northwestern, Chicago, IL, United States, ²College of Medicine, University of Illinois, Chicago, IL, United States, ³Radiology, Northwestern, Chicago, IL, United States

We report the first evidence of diffusion corrected DCE-MRI modeled contrast permeability in intracranial aneurysms and show the diffusion model more accurately represents physiology than previous methods. Permeability metrics, as measured in 23 patients, demonstrate a statistically significant trend with rupture risk as defined by anatomic imaging and clinical risk factors.

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