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Abstract #4386

Diffusion kurtosis imaging for preliminary analysis of micro-structural changes of brain tissue affected by acute ischemic stroke

Liuhong Zhu1, Zhongping Zhang2, Qihua Cheng1, Phillip Zhe Sun3, and Gang Guo1

1Radiology, Xiamen Second Hospital, Xiamen, China, People's Republic of, 2MR Research China, GE Healthcare, Beijing, China, People's Republic of, 3Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

One hundred and thirteen patients with acute ischemic stroke underwent DKI sequence scanning. 131 lesions were outlined and divided into six groups. The changed percentages of DKI indices (FA%, MD%, Da%, Dr%, MK%, Ka%, Kr%) relative to normal contra-lateral ROI were computed. The statistical analysis results illustrated that there was a trend that when the acute ischemic stroke affected tissue mostly contained white matter, the complexity of micro-structure changes of the tissue was much higher than other affected locations. Also, the kurtosis-derived parameters presented to have greater potential in distinguishing each group.

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