Abstract #4389

In Vivo Proton Magnetic Resonance Spectroscopy Reveals Metabolite Changes in a Rat Model of Kainic Acid Induced Spinal Cord Injury

Mingming Zhu¹, Alice H Shum-Siu², Emily Martin³, David S Magnuson², and Chin K Ng¹

¹Department of Diagnostic Radiology, University of Louisville School of Medicine, Louisville, KY, United States, ²Departments of Neurological Surgery, Anatomical Sciences & Neurobiology, and Bioengineering, University of Louisville School of Medicine, Louisville, KY, United States, ³Department of Bioengineering, University of Louisville School of Medicine, Louisville, KY, United States

Current study was to focus on the proton MRS detection of metabolite profile of spinal cord gray matter just caudal to a kainic acid injury in rats 14 days after administration of the excitotoxic agent, and further to correlate the MRS findings to the histopathology of the animal model. Quantitative evaluations of different metabolites were also performed to identify potential MR based biomarkers of neurotoxicity.

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