Abstract #4392

A comprehensive assessment of cervical cord lesions in patients with multiple sclerosis on T1-MPRAGE at 3T: relationship with cord atrophy and disability

Paola Valsasina¹, Maria Assunta Rocca¹, Paolo Preziosa¹, Mohammad Ahmad Abdullah Ali Aboulwafa^1,2, Mark Andrew Horsfield³, Giancarlo Comi⁴, Andrea Falini⁵, and Massimo Filippi¹

¹Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Clinical Neurology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt, ³Xinapse System Ltd, West Bergholt, Essex, United Kingdom, ⁴Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ⁵Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

In this study, we performed a comprehensive assessment of cervical cord lesions in 133 patients with multiple sclerosis (MS) on 3D T1-weighted scans at 3.0 T. Lesion occurrence, regional distribution, influence on cord atrophy and disability were evaluated. T1 lesions were detected in a large proportion (85%) of MS patients, with a higher frequency of cord lesions in the progressive than in the relapsing forms of the disease. There was only a modest correlation between cord T1 lesions and atrophy. Both cord T1 lesions and atrophy were significant and independent contributors to patient disability.

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