Abstract #4391

Demyelination and remyelination: frequency shift assessment in lysolecithin rat model

Evan I Wen Chen¹, Andrew Yung², Barry Bohnet¹, Alexander Rauscher^1,3, and Piotr Kozlowski^1,3

¹MRI Research Center, University of British Columbia, Vancouver, BC, Canada, ²Research Scientist, University of British Columbia, Vancouver, BC, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada

GRE images provide strong gray/white matter contrast that is determined by the local MR resonance frequency, which has been shown to be strongly influenced by the local tissue microstructure. While studies have looked at well-defined architectures in rat spinal cord to study this biophysical mechanism, the specific effects of axon/myelin microstructure on frequency shifts is difficult to evaluate independently. Using lysolecithin to induce chemical demyelination while preserving axonal integrity, we assess predominantly myelin-related effects on frequency shifts in rat dorsal column as it demyelinates/remyelinates, providing insight important to applications of frequency shift mapping to demyelinating diseases such as multiple sclerosis.

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