Abstract #4406

Diffusion basis spectrum imaging (DBSI) reveals axon loss on spinal cord in RRMS and NMO

Peng Sun¹, Kim J. Griffin¹, Robert T. Naismith², Anne H. Cross², and Sheng-Kwei Song¹

¹Radiology, Washington University in St. Louis, St. Louis, MO, United States, ²Neurology, Washington University in St. Louis, St. Louis, MO, United States

DTI failed to detect the extent of axonal loss which plays a significant role in irreversible neurological impairments in MS and NMO patients. Our results suggest diffusion basis spectrum imaging (DBSI) may serve as a useful method to quantify the extent of axonal loss and confounding pathologies in RRMS and NMO.

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