Diffusion basis spectrum imaging (DBSI) reveals axon loss on spinal cord in RRMS and NMO
Peng Sun1, Kim J. Griffin1, Robert T. Naismith2, Anne H. Cross2, and Sheng-Kwei Song1
1Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2Neurology, Washington University in St. Louis, St. Louis, MO, United States
DTI failed to detect the extent of axonal loss which plays
a significant role in irreversible neurological impairments in MS and NMO
patients. Our results suggest diffusion basis spectrum imaging (DBSI) may serve
as a useful method to quantify the extent of axonal loss and confounding
pathologies in RRMS and NMO.
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