Abstract #4415

HARDI Acquisition in Neonates and Children using Modular Multiband Multi-shell Sequence

Vincent Kyu Lee¹, Meredith Monsour², Sudhir Pathak², Vincent Schmithorst³, Catherine Fissell², Ashok Panigrahy^1,3, and Walt Schneider²

¹Radiology, University of Pittsburgh, Pittsburgh, PA, United States, ²University of Pittsburgh, Pittsburgh, PA, United States, ³Children's Hospital of Pittsburgh, Pittsburgh, PA, United States

High angular-resolution diffusion imaging (HARDI) is the best imaging technique to distinguish crossing fibers and high turning angle neuronal tracts, which is critical for identifying and characterizing the microstructural changes in neuro pathology and traumatic brain injury. Its main disadvantage has been the lengthy scan time needed to acquire analyzable images – a challenge especially in children and neonates who do not tolerate long scanning sessions. This study presents the preliminary fiber tractography of healthy neonatal and pediatric subjects acquired using multiband multi-shell HARDI sequence within a practicable scan time without sacrificing image quality.

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