Abstract #4424

Age-specific gray and white matter DTI atlas for human brain at 33 and 36 postmenstrual weeks

Lei Feng^1,2, Hang Li^1,3, Kenichi Oishi⁴, Virendra Mishra⁵, Minhui Ouyang¹, Tina Jeon¹, Yun Peng³, Shuwei Liu², and Hao Huang^1,6

¹Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, ²Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, China, People's Republic of, ³Department of Radiology, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing, China, People's Republic of, ⁴Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ⁵Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁶Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

The large brain morphological differences of the preterm brain at 33 or 36 postmenstrual week (PMW) to that at 40 PMW makes it necessary to establish age-specific atlases for preterm brains. In this study, with diffusion MRI (dMRI) data acquisition of 82 preterm and term normal neonates, we aimed to establish a comprehensive digital atlas including labeling of gray and white matter for preterm brains at 33 and 36 PMW. We demonstrated these atlases and showed the differences of the major neural structures including ganglionic eminence and uncinate fasciculus by comparison to JHU-neonate-SS atlas for brains at around 40PMW.

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