Abstract #4428

A simple method for myelin mapping using T1-weighted, T2-weighted and PD-weighted images

J-Donald Tournier^1,2, Rui Pedro A. G. Teixeira^1,2, Maria Murgasova^1,2, A. David Edwards^2,3, Joseph V. Hajnal^1,2, and Serena J. Counsell^2,3

¹Biomedical Engineering, King's College London, London, United Kingdom, ²Centre for the Developing Brain, King's College London, London, United Kingdom, ³Perinatal Imaging and Health, King's College London, London, United Kingdom

Myelin mapping is of great interest, particularly to study brain development. However, existing methods are time consuming and/or noisy. We propose a simple method to obtain semi-quantitative maps of myelin from routinely acquired T1-, T2- and proton density weighted images, by modelling the signal as a linear combination of non-exchanging tissue types: lipid, tissue water and free water. The method is calibrated empirically from the signal intensities in the data themselves. We show promising results in neonatal scans, showing the expected pattern of myelination in infants at term-equivalent age.

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