Abstract #4427

Age-related white matter changes on phase difference enhanced imaging in children

Tetsu Niwa¹, Tetsuya Yoneda², Shuhei Shibukawa¹, Toshiki Kazama¹, Taro Takahara³, and Yutaka Imai¹

¹Radiology, Tokai University School of Medicine, Isehara, Japan, ²Medical Physics in Advanced Biomedical Sciences, Kumamoto University, Kumamoto, Japan, ³Biomedical Engineering, Tokai University School of Engineering, Isehara, Japan

Recent reports suggest that phase shift in the white matter may be related to myelin content. We assessed the age-related phase changes of the white matter in small children (age range, 0‒6 years) on phase difference enhanced imaging (PADRE). PADRE showed progression of the phase changes in the white matter along with age, particularly in the pyramidal tract and subcortical region in Rolandic are. Whereas, less phase changes were noted in the subcortical white matter in the temporal lobe. PADRE showed age-related white matter phase shift, suggesting progression of myelination and myelin content.

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