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Abstract #4435

Effects of pediatric HIV/antiretroviral therapy on basal ganglia metabolite-volume relationships

Frances C Robertson1, Martha J Holmes1, Emmanuel C Nwosu1, Francesca Little2, Mark F Cotton3, Els Dobbels3, Andre JW van der Kouwe4,5, Barbara Laughton3, and Ernesta M Meintjes1

1Department of Human Biology, University of Cape Town, Cape Town, South Africa, 2Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa, 3Department of Paediatrics & Child Health, Stellenbosch University, Stellenbosch, South Africa, 4A.A. Martinos Centre for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 5Department of Radiology, Harvard Medical School, Boston, MA, United States

HIV is associated with structural deficits in the basal ganglia (BG). Volumes from structural MRI may relate to metabolic changes measurable with magnetic resonance spectroscopy. We investigated the relationship between BG NAA and Glutamate/Glutamine and caudate, putamen, nucleus accumbens and subcortical gray matter (GM) volumes in 7-year old HIV-infected children on antiretroviral therapy and uninfected controls. Higher NAA was associated with smaller accumbens and left putamen in all children. Higher Glutamate/Glutamine was associated with greater subcortical GM in controls, but not HIV-infected children. Relationships between brain metabolites and volumes add to the description of effects of HIV/ART on the BG.

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