Abstract #4436

Mapping Glutamate Changes in the Brain: GluCEST as a Biomarker to Study Localized Glial Function Derangements

Puneet Bagga¹, Rachelle Crescenzi¹, Guruprasad Krishnamoorthy¹, Ravi Prakash Reddy Nanga¹, Damodara Reddy¹, Sidyarth Garimall¹, Kevin D'Aquilla¹, Joel Greenberg², John A Detre², Hari Hariharan¹, and Ravinder Reddy¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) causes selective dopaminergic death in the substantia nigra and striatum leading to dopamine loss in the basal ganglia. Here, we apply glutamate chemical exchange saturation transfer (GluCEST), a novel non-invasive MRI technique, to investigate glutamate changes in MPTP mouse model. The data suggests elevation in GluCEST contrast in striatum and motor cortex of MPTP treated mice. Immunostaining experiments showed elevation of glial markers in the striatum, which correlates with the GluCEST contrast. Also, motor function was found to be negatively correlated with GluCEST.

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