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Abstract #4437

Acute pressure changes in the brain are measurable with MR Elastography: Initial feasibility in an in vivo porcine model

Arvin Arani1, Paul Min1, Nikoo Fattahi1, Nicholas M Wetjen1, Clifford Jack1, Kendall H Lee1, Richard L Ehman1, and John Huston III1

1Mayo Clinic, Rochester, MN, United States

Hydrocephalus is a common medical condition that results from obstruction to the flow of cerebral spinal fluid (CSF) or resorption of CSF. No non-invasive method offers direct measurement of intracranial pressure (ICP). Magnetic resonance elastography (MRE) is capable of non-invasively measuring brain tissue stiffness in-vivo, and may act as a surrogate to ICP. The objective of this study was to investigate the impact of ICP on brain stiffness using MRE in a porcine model. This study shows that MRE brain stiffness changes directly correspond to changes in ICP, motivating future investigation into shunt-therapy monitoring in a patient population.

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