Blanca Lizarbe1, Joao M. N. Duarte1, Ana Francisca Soares1, and Rolf Gruetter1,2,3
1Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Department of Radiology, University of Lausanne, Lausanne, Switzerland, 3Department of Radiology, University of Geneva, Geneva, Switzerland
Obesity is a complex disorder that leads to
reduced life expectancy, with increased risk of heart disease, type-2 diabetes,
high blood pressure and some type of cancers.
To understand the mechanisms of obesity development, several
animal models, such as high fat diet administered rodents, are being studied. We
designed a longitudinal study to investigate the short and long term effects of
high caloric diet intake in two populations of mice -high fat or regular
fed- during 6 months, evaluating in vivo the changes in the neurochemical profile of
the hypothalamus by 1H MRS.