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Abstract #4438

Long term high fat diet modifications of the neurochemical profile of the mouse hypothalamus

Blanca Lizarbe1, Joao M. N. Duarte1, Ana Francisca Soares1, and Rolf Gruetter1,2,3

1Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Department of Radiology, University of Lausanne, Lausanne, Switzerland, 3Department of Radiology, University of Geneva, Geneva, Switzerland

Obesity is a complex disorder that leads to reduced life expectancy, with increased risk of heart disease, type-2 diabetes, high blood pressure and some type of cancers. To understand the mechanisms of obesity development, several animal models, such as high fat diet administered rodents, are being studied. We designed a longitudinal study to investigate the short and long term effects of high caloric diet intake in two populations of mice -high fat or regular fed- during 6 months, evaluating in vivo the changes in the neurochemical profile of the hypothalamus by 1H MRS.

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