Abstract #4438

Long term high fat diet modifications of the neurochemical profile of the mouse hypothalamus

Blanca Lizarbe¹, Joao M. N. Duarte¹, Ana Francisca Soares¹, and Rolf Gruetter^1,2,3

¹Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Department of Radiology, University of Lausanne, Lausanne, Switzerland, ³Department of Radiology, University of Geneva, Geneva, Switzerland

Obesity is a complex disorder that leads to reduced life expectancy, with increased risk of heart disease, type-2 diabetes, high blood pressure and some type of cancers. To understand the mechanisms of obesity development, several animal models, such as high fat diet administered rodents, are being studied. We designed a longitudinal study to investigate the short and long term effects of high caloric diet intake in two populations of mice -high fat or regular fed- during 6 months, evaluating in vivo the changes in the neurochemical profile of the hypothalamus by ¹H MRS.

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