Abstract #4440

TBM and DTI reveal structural changes by memantine treatment in YAC128 mouse model of Huntington disease

Xin Hong¹, Marta Garcia-Miralles², Ling Yun Yeow¹, Xuan Vinh To¹, Benjamin Chaik Meng Yeo¹, Fiftarina Puspitasari¹, Katrianne Bethia Koh², Liang Juin Tan², Mahmoud Abdul Pouladi^2,3, and Kai-Hsiang Chuang¹

¹Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore, ²Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore, Singapore, ³Department of Medicine, National University of Singapore, Singapore, Singapore

T2 weighted structural and diffusion MRI together with behavioral tests were conducted to evaluate the effects of memantine treatment in YAC128 mouse model of Huntington disease. In low-dose (2 mg/kg)-treated YAC128 mice, cognitive functions improved, and increased fractional anisotropy was found in major fiber tracts including the corpus callosum, anterior commissure, and internal capsule. No significant gray matter volume change was detected in treatment groups, though the relative caudate putamen volume showed increasing trend with dose. Our results suggest that low dose memantine treatment had protective effects on white matter in YAC128 mice.

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