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Abstract #4441

A step towards developing MR elastography and diffusion tensor imaging as complementary MR tools to improve the management of hydrocephalus.

Lauriane Jugé 1,2, Alice C. Pong1, Andre Bongers3, Ralph Sinkus4, Lynne E. Bilston1,5, and Shaokoon Cheng6

1Neuroscience Research Australia, Randwick, NSW, Australia, 2School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia, 3Biological Resources Imaging Laboratory, University of New South Wales, Kensington, NSW, Australia, 4BHF Centre of Excellence, Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 5Prince of Wales Clinical School, University of New South Wales, Kensington, NSW, Australia, 6Department of Engineering, Faculty of Science, Macquarie University, North Ryde, NSW, Australia

Hydrocephalus is characterised by enlarged ventricles resulting in compression of surrounding tissues. Conventional imaging techniques depict ventricle size accurately. However, they are limited to detect changes in brain microstructure. The aim of this work was to quantify changes in brain mechanical and diffusion properties during the development of hydrocephalus in rats, using MR Elastography and Diffusion Tensor Imaging. Results showed that both techniques have the potential to be complementary imaging tools for tracking the effects of hydrocephalus on the tissue microstructure and provided new insights on how the brain changes during the course of the disease.

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