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Abstract #4443

High Field MR Demonstrates Effect of Glucocorticoids in a Novel Murine Model of VEGF-Induced Vasogenic Brain Edema

Roger Murayi1, Martin Piazza1, Jeeva Munasinghe1, Nancy Edwards1, Stuart Walbridge1, Marsha Merrill1, and Prashant Chittiboina1

1Surgical Neurology Branch/NINDS, National Institutes of Health, Bethesda, MD, United States

The molecular mechanisms mediating the formation of peritumoral vasogenic brain edema (VBE) and its abrogation from glucocorticoid treatment is poorly understood. In order to study the molecular underpinnings and temporal evolution of these processes we successfully developed a murine model of VBE confirmed by high field MRI and histopathologic studies. Furthermore, we demonstrate a differential effect of systemic glucocorticoids on blood-brain-barrier breakdown and edema formation. This in-vivo model will allow for further investigation into the molecular mechanisms of VBE formation and potentially provide additional targets for its treatment.

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