Abstract #4444

Gray Matter Atrophy in A Rat Model of Chronic Hypoperfusion and The Effects of Environmental Enrichment: A Voxel-based Morphometry Study

Xuxia Wang¹, Ronghui Li¹, and Hao Lei¹

¹National Center of Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China, People's Republic of

Permanent bilateral common carotid arteries occlusion (2VO) rat model can induce pathological changes in brain, do these changes induce MRI visible structural changes? The enriched environment, an useful paradigm of increasing brain structural plasticity, may have a structural effect on 2VO rat brain. In this study the structural changes of 2VO rat brain with and without enriched environment (EE) were studied by in vivo MRI. Our results showed that sensorimotor cortex, dorsolateral striatum, cingulate cortex and dentate gyrus represented significant atrophy after 2VO and EE effectively protected against the gray matter atrophy.

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