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Abstract #4446

Sensitivity and specificity of susceptibility weighted imaging to cerebral microbleeds: A radiologic-neuropathologic correlation study

Karthikeyan Subramanian1, David Utriainen1, Ewart Mark Kaacke1, Charbel Habib1, John Beaver2, and Rajasimhan Rajagovindan2

1Magnetic Resonance Innovations Inc., Detroit, MI, United States, 2Abbvie, North Chicago, IL, United States

This study uses cynomologus macaques, a non-human primate, as an animal model for cerebral microbleeds (CMBs). The intent is to leverage histological slices stained for iron detection against an MRI protocol with susceptibility weighted imaging (SWI) systematically collected over the course of several weeks. The radiologic-neuropathologic assessment of the CMBs was done separately on SWI, T2WI, T2*, SWI phase, and susceptibility weighted imaging and mapping (SWIM). SWIM was also used to quantify the iron content in the basal ganglia structures, such as the caudate nucleus. A quantified increase in CMBs and iron content was observed.

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