Karthikeyan Subramanian1, David Utriainen1, Ewart Mark Kaacke1, Charbel Habib1, John Beaver2, and Rajasimhan Rajagovindan2
1Magnetic Resonance Innovations Inc., Detroit, MI, United States, 2Abbvie, North Chicago, IL, United States
This study uses cynomologus macaques, a non-human primate,
as an animal model for cerebral microbleeds (CMBs). The intent is to leverage histological slices
stained for iron detection against an MRI protocol with susceptibility weighted
imaging (SWI) systematically collected over the course of several weeks. The radiologic-neuropathologic assessment of
the CMBs was done separately on SWI, T2WI, T2*, SWI phase, and susceptibility
weighted imaging and mapping (SWIM).
SWIM was also used to quantify the iron content in the basal ganglia
structures, such as the caudate nucleus.
A quantified increase in CMBs and iron content was observed.