Abstract #4447

Acute high altitude exposure induces ADC change in rat brain

Sunil Koundal^1,2, Sonia Gandhi¹, Tanzeer Kaur², and Subash Khushu¹

¹NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), Delhi, India, ²Department of Biophysics, Panjab University, Chandigarh, India

High altitude hypoxia poses a serious threat to human health. In the present study, rat were exposed to acute simulated high altitude exposure which resulted in apparent diffusion coefficient changes in brain regions including corpus callosum and hippocampus. The study suggested the occurrence of vasogenic edema in corpus callosum and delayed cytotoxic edema in hippocampus region of brain due to acute high altitude exposure. This study has potential in setting new insights to address high altitude related health problems effectively.

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