Abstract #4486

T1 bi-component analysis across whole articular cartilage depth - from calcified cartilage to superficial cartilage

Hongda Shao¹, Soorena Azam ZAnganeh¹, Eric Chang¹, Graeme Bydder¹, and Jiang Du¹

¹Radiology, University of California, San Diego, San Diego, CA, United States

Articular cartilage is a highly ordered tissue with an organized layered structure that can be functionally and structurally divided into the superficial, transitional, radial and the calcified cartilage. By exploiting intrinsic magnetic resonance (MR) properties of cartilage, current techniques allow for the non-invasive assessment of many of the structural components. More recently, ultrashort echo time (UTE) imaging sequences have been used to investigate the T2* relaxation times of bound and free water components in different layers of articular cartilage. However, the depth dependence of longitudinal relaxation times, or T1s are still unknown. In this study we aim to study the T1s of bound and free water in different layers of patella cartilage using UTE imaging sequences on a clinical 3T scanner.

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