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Abstract #4485

MR texture analysis of subchondral bone in osteoarthritis

James MacKay1, Samantha Low1, Philip Murray1, Bahman Kasmai1, Glyn Johnson2, Simon Donell2,3, and Andoni Toms1,2

1Radiology, Norfolk & Norwich University Hospital, Norwich, United Kingdom, 2Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 3Trauma & Orthopaedics, Norfolk & Norwich University Hospital, Norwich, United Kingdom

Subchondral bone (SB) plays an important role in osteoarthritis (OA). Texture analysis (TA) is a method of quantifying changes in SB and may be a useful OA biomarker. The optimum MR method to allow TA of SB is unclear. We compared TA using two sequences which demonstrated promise in depicting SB structure in three groups of participants: normal controls (n=10), individuals with early OA (n=10) and individuals with advanced OA (n=10). TA using a 2D T1-weighted spin echo sequence demonstrated more significant differences in texture features between groups and improved classification accuracy compared to a 3D gradient echo sequence.

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