Abstract #4508

Functional Changes in Medial Gastrocnemius from Unilateral Limb Suspension Induced Acute Atrophy: a 2D Strain Rate Study during Isometric Contraction

Vadim Malis¹, Usha Sinha², Robert Csapo³, and Shantanu Sinha³

¹Physics, University of California at San Diego, San Diego, CA, United States, ²Physics, San Diego State University, San Diego, CA, United States, ³Radiology, University of California at San Diego, San Diego, CA, United States

Unilateral limb suspension is a controlled method to generate acute atrophy. The loss of muscle force with acute atrophy may be due to changes in contractile elements and extracellular matrix (ECM); a study of the strain rate (SR) patterns could provide information on these changes. Subjects were assessed at baseline (pre-ULLS) and post-ULLS using dynamic velocity encoded phase contrast MR imaging. The indices extracted from the SR tensor show at post-ULLS (i) a decrease in the asymmetry of deformation in the fiber cross-section and (ii) larger SR-muscle fiber angles. These findings may reflect a loss of integrity in the ECM.

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