Abstract #4509

Physiological insights into medial gastrocnemius function during eccentric contraction in normal and in acute atrophy – Quantification of 2D strain rate indices from Velocity Encoded Phase Contrast MR Imaging.

Usha Sinha¹, Vadim Malis², Robert Csapo³, and Shantanu Sinha³

¹Physics, San Diego State University, San Diego, CA, United States, ²Physics, University of California at San Diego, San Diego, CA, United States, ³Radiology, University of California at San Diego, San Diego, CA, United States

In-vivo studies of muscle function under different motion paradigms can elucidate the physiology of acute atrophy. This study maps the 2D strain rate tensor in subjects performing eccentric contractions before and after Unilateral Limb Suspension induced acute atrophy. As expected, strain rate values are smaller during eccentric compared to isometric contractions, since in the eccentric mode, muscle contraction occurs under lengthening conditions resulting in a net smaller local elongation. Changes of SR indices with atrophy are negligible possibly due to a balance of force loss from atrophy and greater force generation from a potentially stiffer matrix.

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