Abstract #4510

Feasibility study of interleaved multi-nuclear acquisitions on a 3 T clinical NMR scanner without hardware modifications

Alfredo Liubomir Lopez Kolkovsky^1,2, Benjamin Marty^1,2, Eric Giacomini¹, and Pierre G Carlier^1,2

¹NMR Laboratory, Institut of Myology, Paris, France, ²NMR Laboratory, CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France

NMR allows to investigate multiple aspects of physiological parameters like regional perfusion, blood and tissue oxygenation, intracellular pH or high-energy phosphate metabolism. In the past, interleaved multiparametric multinuclear dynamic NMR imaging and spectroscopy of skeletal muscle was developed on prototype scanners. Here we evaluated an interleaved pulse sequence combining the NMR acquisition of a ¹H image and ³¹P spectrum on a clinical system without any hardware modifications from the customer. Having the possibility to run interleaved multinuclear sequences on unmodified clinical systems will greatly facilitate simultaneous measurements of tissue perfusion, oxygen content and mitochondrial ATP production in clinical research studies.

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