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Abstract #4511

Comparison of T2-prepared 3D TSE with multi-echo spin-echo sequences for T2 mapping of thigh muscles in healthy volunteers

Elisabeth Klupp1, Dominik Weidlich2, Thomas Baum2, Barbara Cervantes2, Marcus Deschauer3, Hendrik Kooijman4, Ernst J. Rummeny2, Claus Zimmer1, Jan S. Kirschke1, and Dimitrios C. Karampinos2

1Neuroradiology, Technische Universität München, München, Germany, 2Radiology, Technische Universität München, München, Germany, 3Neurology, Technische Universität München, München, Germany, 4Philips Healthcare, Hamburg, Germany

There is a growing interest for applying T2 mapping for non-invasively tracking inflammatory changes in patients with neuromuscular diseases. T2 has been traditionally quantified using multi-echo spin-echo (MESE) sequences with known problems related to the refocusing pulses in presence of B1-inhomogeneity and slice profiles effects. The present work proposes the combination of an adiabatic T2-preparation with 3D TSE for B1-insenstive T2 mapping. The proposed method is compared with 2D-MESE and 3D-MESE, in terms of reproducibility on T2 quantification and sensitivity to B1 effects, in the thigh musculature of ten healthy subjects.

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