Abstract #4514

Foot Oximetry Angiosomes with MRI

Jie Zheng¹, David Muccigrosso¹, Xiaodong Zhang², Hongyu An¹, Andrew R Coggan¹, Charles F Hildebolt¹, Chandu Vemuri³, Patrick Geraghty³, Mary K Hastings⁴, and Michael J Mueller⁴

¹Radiology, Washington University in St. Louis, St. Louis, MO, United States, ²Radiology, Peking University First Hospital, Beijing, China, People's Republic of, ³Surgery, Washington University in St. Louis, St. Louis, MO, United States, ⁴The Program in Physical Therapy, Washington University in St. Louis, St. Louis, MO, United States

The objective of this study was to develop a non-contrast MRI based oximetry approach to assess the skeletal muscle microcirculation in diabetic and healthy feet. In both healthy and subjects with diabetes, the feasibility of the foot oximetry was examined when the subjects were at rest and during a toe-flexion isometric exercise. The percent difference in the areas of the oxygen extraction fraction within the 0.7 – 1.0 range between rest and exercise was significantly different between healthy subjects and subjects with diabetes. This is the first MRI foot oximetry developed for assessing regional skeletal muscle oxygenation.

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