Abstract #4513

Quantitative Assessment of Muscle Fat in Sarcopenia Using Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS)

Alexandra Grimm^1,2, Heiko Meyer², Mathias Nittka², Esther Raithel², Andreas Friedberger¹, Marc Teschler¹, Michael Uder³, Wolfgang Kemmler¹, Klaus Engelke¹, and Harald H. Quick^1,4

¹Institute of Medical Physics, Erlangen, Germany, ²Product Definition & Innovation, Siemens Healthcare GmbH, Erlangen, Germany, ³Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, ⁴Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany

Sarcopenia describes muscle degeneration. In particular with increasing age, muscle tissue is replaced by fatty infiltrations. We developed an MRI sequence protocol (T₁w TSE, PDw SPACE, PDw TSE Dixon, q-Dixon, and HISTO) for quantifying this degradation and applied it twice to 54 patients suffering from sarcopenia. Between both measurements three months of whole body electromyostimulation (EMS) training were performed. Initial results show that image data can be used for muscle segmentation and determination of muscle volumes, fat fractions, and fat distribution within the muscles. Muscle fat fractions correlate with muscle strength. In spectroscopy accurate voxel repositioning is challenging.

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